Pathogen subversion of neuro-epidermal signaling impairs lysosomal function to disrupt collagen homeostasis in Caenorhabditis elegans

Qian Li; Yating Liu; Hanyi Chen; Weilie Xiao; Bin Qi

doi:10.1371/journal.pbio.3004016

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Peer-reviewed

Research Article

Pathogen subversion of neuro-epidermal signaling impairs lysosomal function to disrupt collagen homeostasis in Caenorhabditis elegans

Qian Li ,

Contributed equally to this work with: Qian Li, Yating Liu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, China, School of Chemical Science and Technology, Key Laboratory of Medicinal Chemistry for Natural Resource - Ministry of Education, Yunnan University, Kunming, China
⨯
Yating Liu ,

Contributed equally to this work with: Qian Li, Yating Liu

Roles Data curation, Investigation, Validation

Affiliation School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, China
⨯
Hanyi Chen,

Roles Data curation, Investigation

Affiliation School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, China
⨯
Weilie Xiao,

Roles Resources

Affiliation School of Chemical Science and Technology, Key Laboratory of Medicinal Chemistry for Natural Resource - Ministry of Education, Yunnan University, Kunming, China
⨯
Bin Qi

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: qb@ynu.edu.cn

Affiliation School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, China

https://orcid.org/0000-0003-2261-1550

⨯

Pathogen subversion of neuro-epidermal signaling impairs lysosomal function to disrupt collagen homeostasis in Caenorhabditis elegans

Qian Li,
Yating Liu,
Hanyi Chen,
Weilie Xiao,
Bin Qi

Published: September 22, 2026
https://doi.org/10.1371/journal.pbio.3004016

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Lysosomes
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Plasmid construction
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Caenorhabditis elegans
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Fluorescence imaging
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Gonads
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Collagens
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Epidermis
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