MucD regulates alginate biosynthesis through the proteolytic control of AlgX and AlgK in Pseudomonas aeruginosa

Yujun Jiang; Xin-Fu Yan; Rya Ero; Chao Wang; Kanaga Sabapathy; Yong-Gui Gao

doi:10.1371/journal.pbio.3003985

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MucD regulates alginate biosynthesis through the proteolytic control of AlgX and AlgK in Pseudomonas aeruginosa

Yujun Jiang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore
⨯
Xin-Fu Yan,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – review & editing

Affiliations School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore
⨯
Rya Ero,

Roles Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore
⨯
Chao Wang,

Roles Methodology, Validation, Visualization, Writing – review & editing

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
⨯
Kanaga Sabapathy,

Roles Supervision

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
⨯
Yong-Gui Gao

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ygao@ntu.edu.sg

Affiliations School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore

https://orcid.org/0000-0001-7298-0835

⨯

MucD regulates alginate biosynthesis through the proteolytic control of AlgX and AlgK in Pseudomonas aeruginosa

Yujun Jiang,
Xin-Fu Yan,
Rya Ero,
Chao Wang,
Kanaga Sabapathy,
Yong-Gui Gao

Published: September 21, 2026
https://doi.org/10.1371/journal.pbio.3003985

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Proteases
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Pseudomonas aeruginosa
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Biosynthesis
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Proteolysis
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Gel filtration
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Oligomers
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Sequence alignment
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Electron cryo-microscopy
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