Hyperglycemic stress aggravates diabetic retinopathy and nephropathy by promoting cilium disassembly via a deacetylation- and methylation-mediated regulatory mechanism

• Jie Ran ,

  Contributed equally to this work with: Jie Ran, Changfeng Wei, Yang Yang

  Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jran@sdnu.edu.cn (JR), minliu@sdnu.edu.cn (ML)

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  https://orcid.org/0000-0002-0744-7126

  ⨯
• Changfeng Wei ,

  Contributed equally to this work with: Jie Ran, Changfeng Wei, Yang Yang

  Roles Data curation, Investigation, Validation, Writing – original draft

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Yang Yang ,

  Contributed equally to this work with: Jie Ran, Changfeng Wei, Yang Yang

  Roles Formal analysis, Funding acquisition, Methodology

  Affiliation Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

  ⨯
• Yufei Zhang,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Guizhi Guo,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Nan Ma,

  Roles Methodology, Software

  Affiliation Department of Genetics and Cell Biology, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China

  ⨯
• Long Yin,

  Roles Data curation, Formal analysis

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Hongjun Fan,

  Roles Validation, Visualization

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Jingrui Li,

  Roles Data curation, Resources

  Affiliation School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China

  ⨯
• Heng Guo,

  Roles Methodology, Validation

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Renshuai Zhang,

  Roles Data curation, Visualization

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Runa Wang,

  Roles Validation, Visualization

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯
• Dengwen Li,

  Roles Methodology, Project administration

  Affiliation Department of Genetics and Cell Biology, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China

  ⨯
• Min Liu

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: jran@sdnu.edu.cn (JR), minliu@sdnu.edu.cn (ML)

  Affiliation Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China

  ⨯