Engineering inter-kingdom adrenergic signaling in commensals couples host stress hormone sensing to programmable biological outputs

Santosh Kumar Srivastava; Guo Wei Foo; Haosheng Shen; Yuanzhi He; Kwok Soon Wun; In Young Hwang; Michael S. Goodson; Nikhil Aggarwal; Matthew Wook Chang

doi:10.1371/journal.pbio.3003926

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Engineering inter-kingdom adrenergic signaling in commensals couples host stress hormone sensing to programmable biological outputs

Santosh Kumar Srivastava,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Conceptualization

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, National Centre for Engineering Biology (NCEB), Singapore, Singapore, School of Healthcare Science and Engineering (SHINE), Vellore Institute of Technology, Vellore, India
⨯
Guo Wei Foo,

Roles Formal analysis, Investigation

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, National Centre for Engineering Biology (NCEB), Singapore, Singapore
⨯
Haosheng Shen,

Roles Formal analysis, Investigation

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, National Centre for Engineering Biology (NCEB), Singapore, Singapore
⨯
Yuanzhi He,

Roles Formal analysis, Investigation

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, National Centre for Engineering Biology (NCEB), Singapore, Singapore
⨯
Kwok Soon Wun,

Roles Formal analysis, Investigation

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, National Centre for Engineering Biology (NCEB), Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
In Young Hwang,

Roles Formal analysis, Investigation

Current address: Food, Chemical and Biotechnology, Singapore Institute of Technology, Singapore, Singapore

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Michael S. Goodson,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation United States Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, Ohio, United States of America
⨯
Nikhil Aggarwal,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, National Centre for Engineering Biology (NCEB), Singapore, Singapore
⨯
Matthew Wook Chang

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

* E-mail: bchcmw@nus.edu.sg

Affiliations NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore, Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, National Centre for Engineering Biology (NCEB), Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

https://orcid.org/0000-0001-6448-6319

⨯

Engineering inter-kingdom adrenergic signaling in commensals couples host stress hormone sensing to programmable biological outputs

Santosh Kumar Srivastava,
Guo Wei Foo,
Haosheng Shen,
Yuanzhi He,
Kwok Soon Wun,
In Young Hwang,
Michael S. Goodson,
Nikhil Aggarwal,
Matthew Wook Chang

Published: August 25, 2026
https://doi.org/10.1371/journal.pbio.3003926

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