Meis1 isoform diversity orchestrates neural progenitor differentiation by regulating ATOH1 degradation at distinct subcellular compartments

• Tomoo Owa ,

  Contributed equally to this work with: Tomoo Owa, Toma Adachi

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: owa@ncnp.go.jp (TO); hoshino@ncnp.go.jp (MH)

  Affiliation Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

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• Toma Adachi ,

  Contributed equally to this work with: Tomoo Owa, Toma Adachi

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

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• Ryo Shiraishi,

  Roles Conceptualization, Investigation, Resources, Writing – review & editing

  Affiliation Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

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• Kentaro Ichijo,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan, Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

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• Kaiyuan Ji,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan

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• Minami Mizuno,

  Roles Writing – review & editing, Investigation

  Affiliations Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan, Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan

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• Kyoka Suyama,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan

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• Kayo Nishitani,

  Roles Investigation

  Affiliation Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

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• Ikuko Hasegawa,

  Roles Investigation

  Affiliation Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

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• Masaki Sone,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan

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• Daisuke Kawauchi,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan, Department of Neuro-oncology, Institute of Brain Science, Graduate School of Medical Sciences, Nagoya City University, Aichi, Japan

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• Tomoki Nishioka,

  Roles Investigation, Writing – review & editing

  Affiliation International Center for Brain Sciences, Fujita Health University, Aichi, Japan

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• Shinichiro Taya ,

  Roles Investigation, Writing – review & editing

  ¶Deceased on May 10, 2024.

  Affiliation Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

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• Yutaka Suzuki,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

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• Kozo Kaibuchi,

  Roles Investigation, Writing – review & editing

  Affiliation International Center for Brain Sciences, Fujita Health University, Aichi, Japan

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• Satoshi Miyashita,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

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•  [ ... ],
• Mikio Hoshino

  Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing, Conceptualization

  * E-mail: owa@ncnp.go.jp (TO); hoshino@ncnp.go.jp (MH)

  Affiliations Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan

  https://orcid.org/0000-0002-9526-3473

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