Queuosine tRNA modification regulates translational adaptation and virulence of Leishmania mexicana

Bankatesh Kumar; Julie Kovářová; Michala Boudová; Sneha Kulkarni; Thalia Pacheco Fernandez; Abhay Satoskar; Zdeněk Paris

doi:10.1371/journal.pbio.3003887

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Peer-reviewed

Research Article

Queuosine tRNA modification regulates translational adaptation and virulence of Leishmania mexicana

Bankatesh Kumar,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic
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Julie Kovářová,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic
⨯
Michala Boudová,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliations Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic
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Sneha Kulkarni,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic
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Thalia Pacheco Fernandez,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Pathology and Microbiology, Ohio State University, Columbus, Ohio, United States of America
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Abhay Satoskar,

Roles Formal analysis, Resources, Supervision, Writing – review & editing

Affiliation Department of Pathology and Microbiology, Ohio State University, Columbus, Ohio, United States of America
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Zdeněk Paris

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: parda@paru.cas.cz

Affiliations Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic

https://orcid.org/0000-0003-1019-7719

⨯

Queuosine tRNA modification regulates translational adaptation and virulence of Leishmania mexicana

Bankatesh Kumar,
Julie Kovářová,
Michala Boudová,
Sneha Kulkarni,
Thalia Pacheco Fernandez,
Abhay Satoskar,
Zdeněk Paris

Published: July 17, 2026
https://doi.org/10.1371/journal.pbio.3003887

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Parasitic diseases
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Cell differentiation
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Transfer RNA
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Macrophages
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Protein translation
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Leishmania
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Proteomic databases
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Gene expression
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