The zinc-finger protein ZC3H10 suppresses type I interferon responses during viral infection by repressing interferon-stimulated gene promoters

Xiaojing Dong; Xiaoyan Zuo; Xia Xiao; Shichao Ma; Lili Ren; Zhuo Zhou; Xiaobo Lei; Jianwei Wang

doi:10.1371/journal.pbio.3003881

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Open Access

Peer-reviewed

Research Article

The zinc-finger protein ZC3H10 suppresses type I interferon responses during viral infection by repressing interferon-stimulated gene promoters

Xiaojing Dong ,

Contributed equally to this work with: Xiaojing Dong, Xiaoyan Zuo

Roles Investigation, Methodology, Software, Writing – original draft

Affiliations NHC Key Laboratory of System Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, Christophe Merieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China, Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Beijing, P.R. China, Beijing Key Laboratory of Surveillance, Early Warning and Pathogen Research on Emerging Infectious Diseases, Beijing Center for Disease Prevention and Control, Beijing, P.R. China, Beijing Research Center for Respiratory Infectious Diseases, Beijing, P.R. China, School of Public Health, Capital Medical University, Beijing, P.R. China
⨯
Xiaoyan Zuo ,

Contributed equally to this work with: Xiaojing Dong, Xiaoyan Zuo

Roles Investigation, Software, Validation, Writing – original draft

Affiliations NHC Key Laboratory of System Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, Christophe Merieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China, Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Beijing, P.R. China
⨯
Xia Xiao,

Roles Data curation, Formal analysis, Methodology, Software

Affiliations NHC Key Laboratory of System Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, Christophe Merieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China, Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Beijing, P.R. China
⨯
Shichao Ma,

Roles Investigation, Methodology

Affiliation NHC Key Laboratory of System Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, Christophe Merieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China
⨯
Lili Ren,

Roles Conceptualization, Project administration, Resources

Affiliations NHC Key Laboratory of System Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, Christophe Merieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China, Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Beijing, P.R. China
⨯
Zhuo Zhou ,

Roles Conceptualization, Funding acquisition, Data curation, Formal analysis, Resources, Supervision

* E-mail: zhouzhuo@gmail.com (ZZ); fyleixb@126.com (XL); wangjw28@163.com (JW)

Affiliation State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, P.R. China
⨯
Xiaobo Lei ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: zhouzhuo@gmail.com (ZZ); fyleixb@126.com (XL); wangjw28@163.com (JW)

Affiliations NHC Key Laboratory of System Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, Christophe Merieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China, Key Laboratory of Pathogen Infection Prevention and Control, Ministry of Education, Beijing, P.R. China
⨯
Jianwei Wang

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: zhouzhuo@gmail.com (ZZ); fyleixb@126.com (XL); wangjw28@163.com (JW)

Affiliation NHC Key Laboratory of System Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, Christophe Merieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China

https://orcid.org/0000-0002-1116-4559

⨯

The zinc-finger protein ZC3H10 suppresses type I interferon responses during viral infection by repressing interferon-stimulated gene promoters

Xiaojing Dong,
Xiaoyan Zuo,
Xia Xiao,
Shichao Ma,
Lili Ren,
Zhuo Zhou,
Xiaobo Lei,
Jianwei Wang

Published: July 16, 2026
https://doi.org/10.1371/journal.pbio.3003881

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Interferons
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Transfection
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Regulator genes
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Protein expression
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Zinc finger domains
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