Neuronal protein Sex-lethal modulates tRNA synthesis via the polymerase III subunit Polr3E in male Drosophila neurons

Freya Storer; Colin D. McClure; Alicia Estacio Gomez; Lucy J. Minkley; Tsz Lam Wong; Nina Markevych; Tony D. Southall

doi:10.1371/journal.pbio.3003863

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Peer-reviewed

Research Article

Neuronal protein Sex-lethal modulates tRNA synthesis via the polymerase III subunit Polr3E in male Drosophila neurons

Freya Storer ,

Contributed equally to this work with: Freya Storer, Colin D. McClure

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: f.storer@imperial.ac.uk (FS); t.southall@imperial.ac.uk (TDS)

Affiliation Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, London, United Kingdom
⨯
Colin D. McClure ,

Contributed equally to this work with: Freya Storer, Colin D. McClure

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

Current address: School of Biological Sciences, Queen’s University Belfast, Belfast, United Kingdom

Affiliation Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, London, United Kingdom
⨯
Alicia Estacio Gomez,

Roles Formal analysis, Investigation

Affiliation Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, London, United Kingdom
⨯
Lucy J. Minkley,

Roles Formal analysis, Investigation

Affiliation School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, United Kingdom
⨯
Tsz Lam Wong,

Roles Formal analysis, Investigation

Affiliation Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, London, United Kingdom
⨯
Nina Markevych,

Roles Formal analysis, Investigation

Affiliation Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, London, United Kingdom
⨯
Tony D. Southall

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: f.storer@imperial.ac.uk (FS); t.southall@imperial.ac.uk (TDS)

Affiliation Department of Life Sciences, Imperial College London, Sir Ernst Chain Building, London, United Kingdom

https://orcid.org/0000-0002-8645-4198

⨯

Neuronal protein Sex-lethal modulates tRNA synthesis via the polymerase III subunit Polr3E in male Drosophila neurons

Freya Storer,
Colin D. McClure,
Alicia Estacio Gomez,
Lucy J. Minkley,
Tsz Lam Wong,
Nina Markevych,
Tony D. Southall

Published: July 17, 2026
https://doi.org/10.1371/journal.pbio.3003863

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Gene expression
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Transfer RNA
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Neurons
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Drosophila melanogaster
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