Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex

Jiasong Li; Lingwei Tang; Xinhang Wei; Yumin Chen; Haibing Xu

doi:10.1371/journal.pbio.3003824

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Peer-reviewed

Research Article

Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex

Jiasong Li ,

Contributed equally to this work with: Jiasong Li, Lingwei Tang

Roles Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Key Laboratory of Mental Health of the Ministry of Education, Guangdong‑Hong Kong‑Macao Greater Bay Area Center for Brain Science and Brain‑Inspired Intelligence, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Lingwei Tang ,

Contributed equally to this work with: Jiasong Li, Lingwei Tang

Roles Data curation, Formal analysis, Methodology, Resources, Validation

Affiliation Key Laboratory of Mental Health of the Ministry of Education, Guangdong‑Hong Kong‑Macao Greater Bay Area Center for Brain Science and Brain‑Inspired Intelligence, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Xinhang Wei,

Roles Methodology, Resources, Software

Affiliation Key Laboratory of Mental Health of the Ministry of Education, Guangdong‑Hong Kong‑Macao Greater Bay Area Center for Brain Science and Brain‑Inspired Intelligence, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Yumin Chen,

Roles Methodology, Resources, Software

Affiliation Key Laboratory of Mental Health of the Ministry of Education, Guangdong‑Hong Kong‑Macao Greater Bay Area Center for Brain Science and Brain‑Inspired Intelligence, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⨯
Haibing Xu

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: haibingxu@smu.edu.cn

Affiliation Key Laboratory of Mental Health of the Ministry of Education, Guangdong‑Hong Kong‑Macao Greater Bay Area Center for Brain Science and Brain‑Inspired Intelligence, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China

https://orcid.org/0009-0005-4788-9294

⨯

Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex

Jiasong Li,
Lingwei Tang,
Xinhang Wei,
Yumin Chen,
Haibing Xu

Published: May 29, 2026
https://doi.org/10.1371/journal.pbio.3003824

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