Structure of the human P2X3 receptor reveals the basis for subtype-selective inhibition by sivopixant

• Zhixuan Zhao ,

  Contributed equally to this work with: Zhixuan Zhao, Dong-Ping Wang

  Roles Data curation, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, China

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• Dong-Ping Wang ,

  Contributed equally to this work with: Zhixuan Zhao, Dong-Ping Wang

  Roles Data curation, Formal analysis, Funding acquisition, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

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• Xin Zhang,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

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• Yuan Gao,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

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• Hexin Xu,

  Roles Formal analysis

  Affiliation State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, China

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• Xinyu Teng,

  Roles Formal analysis

  Affiliation State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, China

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• Cheng Shen,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, China

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• Jirui Chen,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, China

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• Jinru Zhang,

  Roles Methodology

  Affiliation State Key Laboratory of Genetics and Development of Complex Phenotypes, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai, China

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• Chang-Run Guo ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: gcr@cpu.edu.cn (C-RG); hattorim@fudan.edu.cn (MH)

  Affiliation State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

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• Motoyuki Hattori

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: gcr@cpu.edu.cn (C-RG); hattorim@fudan.edu.cn (MH)

  Affiliation State Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, China

  https://orcid.org/0000-0002-5327-5337

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