Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a

Abhimanyu Kiran; Peter A. Thomason; David M. Versluis; Peggy I. Paschke; Hannah Donnelly; Luke Tweedy; Sergio Lilla; Isabel Bravo-Ferrer; Amy Shergold; Ryan Devlin; Edward W. Roberts; Robert H. Insall

doi:10.1371/journal.pbio.3003728

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Open Access

Peer-reviewed

Research Article

Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a

Abhimanyu Kiran,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom, Division of Cell & Developmental Biology, University College London, London, United Kingdom
⨯
Peter A. Thomason,

Roles Investigation, Validation

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
David M. Versluis,

Roles Investigation, Methodology, Software, Visualization

Affiliation Division of Cell & Developmental Biology, University College London, London, United Kingdom
⨯
Peggy I. Paschke,

Roles Resources

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
Hannah Donnelly,

Roles Resources, Validation

Current address: School of Molecular Biosciences, University of Glasgow, Glasgow, United Kingdom

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
Luke Tweedy,

Roles Methodology, Software

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
Sergio Lilla,

Roles Investigation

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
Isabel Bravo-Ferrer,

Roles Resources, Writing – review & editing

Affiliation Division of Cell & Developmental Biology, University College London, London, United Kingdom
⨯
Amy Shergold,

Roles Resources, Validation

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
Ryan Devlin,

Roles Resources, Writing – review & editing

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
Edward W. Roberts,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom
⨯
Robert H. Insall

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: R.Insall@ucl.ac.uk

Affiliations CRUK Scotland Institute, Bearsden, Glasgow, United Kingdom, Division of Cell & Developmental Biology, University College London, London, United Kingdom

https://orcid.org/0000-0003-4898-040X

⨯

Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a

Abhimanyu Kiran,
Peter A. Thomason,
David M. Versluis,
Peggy I. Paschke,
Hannah Donnelly,
Luke Tweedy,
Sergio Lilla,
Isabel Bravo-Ferrer,
Amy Shergold,
Ryan Devlin

Published: April 2, 2026
https://doi.org/10.1371/journal.pbio.3003728

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Macrophages
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Chemotaxis
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Wavefronts
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Endocytosis
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