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Open Access
Peer-reviewed
Research Article
Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta
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Hannah N. Gruner ,
Contributed equally to this work with: Hannah N. Gruner, C. J. Pickett
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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C. J. Pickett ,
Contributed equally to this work with: Hannah N. Gruner, C. J. Pickett
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Jasmine Yimeng Bao,
Roles Formal analysis, Investigation, Methodology
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Richard Garcia,
Roles Investigation, Methodology
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Akiko Hozumi,
Roles Investigation, Visualization
Affiliation Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan
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Tal D. Scully,
Roles Formal analysis, Validation
Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
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Sydney Popsuj,
Roles Validation, Writing – review & editing
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Shaoyang Ning,
Roles Formal analysis, Methodology
Affiliation Department of Mathematics and Statistics, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Mavis Gao,
Roles Investigation, Visualization
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Gia Bautista,
Roles Investigation, Visualization
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Keren Maze,
Roles Investigation, Visualization
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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HaEun Karissa Lim,
Roles Investigation, Visualization
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Tomohiro Osugi,
Roles Investigation
Affiliation The Bioorganic Research Institute, Suntory Foundation for Life Sciences (SUNBOR), Kyoto, Japan
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Mae Collins-Doijode,
Roles Investigation, Visualization
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Ofubofu Cairns,
Roles Investigation
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Gabriel Levis,
Roles Investigation
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Shu Yi Chen,
Roles Investigation
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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TaiXi Gong,
Roles Investigation
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Honoo Satake,
Roles Investigation
Affiliation The Bioorganic Research Institute, Suntory Foundation for Life Sciences (SUNBOR), Kyoto, Japan
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Allon Moshe Klein,
Roles Methodology, Validation
Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
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Yasunori Sasakura,
Roles Investigation, Methodology, Resources, Visualization, Writing – review & editing
Affiliation Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan
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Bradley Davidson
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: bdavids1@swarthmore.edu
Affiliation Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, United States of America
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Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta
- Hannah N. Gruner,
- C. J. Pickett,
- Jasmine Yimeng Bao,
- Richard Garcia,
- Akiko Hozumi,
- Tal D. Scully,
- Sydney Popsuj,
- Shaoyang Ning,
- Mavis Gao,
- Gia Bautista
- Published: April 14, 2026
- https://doi.org/10.1371/journal.pbio.3003715