Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells

• Chenyang Ma ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ Co-first authors.

  Affiliations Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women’s Hospital, and School of Medicine, Zhejiang University, Hangzhou, China, Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China

  ⨯
• Weikang Meng ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ Co-first authors.

  Affiliations Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women’s Hospital, and School of Medicine, Zhejiang University, Hangzhou, China, Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China

  ⨯
• Jinghan Huang ,

  Roles Formal analysis, Investigation, Methodology, Software, Writing – review & editing

  ¶☯ Co-first authors.

  Affiliations Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China, School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China

  ⨯
• Wanling Zheng ,

  Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

  ¶☯ Co-first authors.

  Affiliations Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China, Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Xiao Xu,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women’s Hospital, and School of Medicine, Zhejiang University, Hangzhou, China, Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China

  ⨯
• Tao Cheng,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China, Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Zhengyi Li,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women’s Hospital, and School of Medicine, Zhejiang University, Hangzhou, China, Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China

  ⨯
• Yang Liu,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliations Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women’s Hospital, and School of Medicine, Zhejiang University, Hangzhou, China, Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China

  ⨯
• Hao Shen,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women’s Hospital, and School of Medicine, Zhejiang University, Hangzhou, China, Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China

  ⨯
• Feng He,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliations Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China, Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Alessandro Esposito,

  Roles Methodology, Writing – review & editing

  Affiliation Centre for Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom

  ⨯
• Pengfei Xu,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliations Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China, Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

  ⨯
• Ashok Venkitaraman,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore

  ⨯
• Jun Ma ,

  Roles Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jun_ma@zju.edu.cn (JM); Heng_Xu@sjtu.edu.cn (HX); lianghongqing@zju.edu.cn (HL)

  Affiliations Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China, Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

  https://orcid.org/0000-0002-1609-3294

  ⨯
• Heng Xu ,

  Roles Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jun_ma@zju.edu.cn (JM); Heng_Xu@sjtu.edu.cn (HX); lianghongqing@zju.edu.cn (HL)

  Affiliations Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China, School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China

  https://orcid.org/0000-0002-3717-0412

  ⨯
•  [ ... ],
• Hongqing Liang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jun_ma@zju.edu.cn (JM); Heng_Xu@sjtu.edu.cn (HX); lianghongqing@zju.edu.cn (HL)

  ¶‡ Lead contact.

  Affiliations Division of Human Reproduction and Developmental Genetics, Key Laboratory of Reproductive Genetics (Ministry of Education), Women’s Hospital, and School of Medicine, Zhejiang University, Hangzhou, China, Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China

  https://orcid.org/0000-0002-5494-2197

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