Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown

Kenan Zhang; Zihan Luo; Yan Chen; Yan Li; Lang Wang; Yanan Liu; Ruizhi Yang; Qian Li; Jiahao Zhao; Bin Qi; Zhao Shan

doi:10.1371/journal.pbio.3003685

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Open Access

Peer-reviewed

Research Article

Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown

Kenan Zhang ,

Contributed equally to this work with: Kenan Zhang, Zihan Luo

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Zihan Luo ,

Contributed equally to this work with: Kenan Zhang, Zihan Luo

Roles Data curation, Investigation, Methodology, Validation

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Yan Chen,

Roles Methodology, Investigation

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Yan Li,

Roles Investigation

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Lang Wang,

Roles Methodology

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Yanan Liu,

Roles Methodology

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Ruizhi Yang,

Roles Methodology

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Qian Li,

Roles Methodology

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Jiahao Zhao,

Roles Methodology

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China
⨯
Bin Qi ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: qb@ynu.edu.cn (BQ); shanzhaolab@163.com (ZS)

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China

https://orcid.org/0000-0003-2261-1550

⨯
Zhao Shan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: qb@ynu.edu.cn (BQ); shanzhaolab@163.com (ZS)

Affiliation School of Life Sciences, Center for Life Sciences, Southwest United Graduate School, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China

https://orcid.org/0000-0001-5064-1023

⨯

Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown

Kenan Zhang,
Zihan Luo,
Yan Chen,
Yan Li,
Lang Wang,
Yanan Liu,
Ruizhi Yang,
Qian Li,
Jiahao Zhao,
Bin Qi

Published: February 26, 2026
https://doi.org/10.1371/journal.pbio.3003685

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Lysosomes
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Tryptophan
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Lipid metabolism
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Escherichia coli
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Indoles
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Fluorescence imaging
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Lipids
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