Disrupting CD22-cis-ligand interactions ameliorates type 1 diabetes and graft rejection by expanding regulatory B cells

• Wang Long,

  Roles Investigation, Writing – original draft

  Affiliations Department of Pathology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan, Department of Immunology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

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• Ayaka Endo,

  Roles Investigation

  Affiliation Department of Immunology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

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• Hashadi Nadeesha Walakulu Gamage,

  Roles Investigation

  Affiliations Department of Pathology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan, Department of Immunology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan, Department of Structural Biology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

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• Tianyi Yang,

  Roles Investigation

  Affiliation Department of Immunology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

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• Toru Suzuki,

  Roles Methodology

  Affiliations Laboratory of Genome Editing for Biomedical Research, Medical Research Laboratory, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan, Animal Research Facilities, Bioscience Center, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

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• Takeshi Nitta,

  Roles Methodology

  Affiliation Division of Molecular Pathology, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan

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• Hiromu Takematsu,

  Roles Methodology

  Affiliation Department of Molecular Cell Biology, School of Medical Sciences, Fujita Health University, Toyoake, Aichi, Japan

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• Kenya Honda,

  Roles Methodology

  Affiliations Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan

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• Masatake Asano ,

  Roles Supervision

  ¶Deceased.

  Affiliation Department of Pathology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan

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• Takeshi Tsubata

  Roles Conceptualization, Funding acquisition, Writing – original draft

  * E-mail: tsubata.imm@mri.tmd.ac.jp

  Affiliations Department of Pathology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan, Department of Immunology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

  https://orcid.org/0000-0003-0760-1258

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