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Open Access
Peer-reviewed
Research Article
Oligomeric lactic acid nanoplastics induce intrauterine growth restriction in mice by disrupting GATA2-mediated placental vascular development
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Jia Lv ,
Contributed equally to this work with: Jia Lv, Mengjing Wang
Roles Data curation, Investigation, Methodology, Writing – original draft
Affiliations School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China, Clinical Research Center, Suzhou Hospital of Anhui Medical University, Suzhou, China
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Mengjing Wang ,
Contributed equally to this work with: Jia Lv, Mengjing Wang
Roles Data curation, Investigation, Methodology, Writing – original draft
Affiliation Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, California, United States of America
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Changzhi Shi,
Roles Data curation, Formal analysis, Investigation, Methodology, Software
Affiliation Department of Environmental Science and Engineering, Fudan University, Shanghai, China
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Yanwei Wang,
Roles Formal analysis, Investigation, Methodology
Affiliations Department of Environmental Science and Engineering, Fudan University, Shanghai, China, Department of Pharmacology, College of Medicine, Jiaxing University, Jiaxing, China
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Yihao Zhang,
Roles Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China
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Chang Gao,
Roles Data curation, Formal analysis, Investigation, Resources, Software
Affiliations School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China, Clinical Research Center, Suzhou Hospital of Anhui Medical University, Suzhou, China
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Tian-Qi Bi,
Roles Investigation, Methodology
Affiliation School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China
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Jing Yang,
Roles Investigation, Methodology, Resources, Software
Affiliation Department of Environmental Science and Engineering, Fudan University, Shanghai, China
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Youdong Xu,
Roles Investigation, Methodology, Project administration, Software
Affiliation State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China
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Qunan Wang,
Roles Investigation, Methodology, Software
Affiliation School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China
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Hua Wang,
Roles Investigation, Methodology, Resources, Software
Affiliation School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China
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De-Xiang Xu ,
Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: xudex@ahmu.edu.cn (D-XX); mlfang@fudan.edu.cn (MF); yichao.huang@ahmu.edu.cn (YH)
Affiliation School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China
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Mingliang Fang ,
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: xudex@ahmu.edu.cn (D-XX); mlfang@fudan.edu.cn (MF); yichao.huang@ahmu.edu.cn (YH)
Affiliation Department of Environmental Science and Engineering, Fudan University, Shanghai, China
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Yichao Huang
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: xudex@ahmu.edu.cn (D-XX); mlfang@fudan.edu.cn (MF); yichao.huang@ahmu.edu.cn (YH)
Affiliations School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Center for Big Data and Population Health of IHM and MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China, Clinical Research Center, Suzhou Hospital of Anhui Medical University, Suzhou, China
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Oligomeric lactic acid nanoplastics induce intrauterine growth restriction in mice by disrupting GATA2-mediated placental vascular development
- Jia Lv,
- Mengjing Wang,
- Changzhi Shi,
- Yanwei Wang,
- Yihao Zhang,
- Chang Gao,
- Tian-Qi Bi,
- Jing Yang,
- Youdong Xu,
- Qunan Wang
- Published: March 26, 2026
- https://doi.org/10.1371/journal.pbio.3003676