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Open Access
Peer-reviewed
Update Article
Update Articles develop a previous PLOS Biology study by providing new mechanistic insight, identifying the biological or physiological significance of the previous findings, or in another way significantly adding to the original article.
Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans
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Kai Mi,
Roles Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
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Lili Guan,
Roles Resources
Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China, Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Bandhan Sarker,
Roles Methodology
Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
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Siliang Song,
Roles Methodology
Affiliation Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Tianjiao Zhou,
Roles Resources
Affiliation Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Hongliang Yi,
Roles Resources
Affiliation Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Jianzhi Zhang ,
Roles Conceptualization, Funding acquisition, Writing – review & editing
* E-mail: jianzhi@umich.edu (JZ); chuanx@sjtu.edu.cn (CX)
Affiliation Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
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Chuan Xu
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing
* E-mail: jianzhi@umich.edu (JZ); chuanx@sjtu.edu.cn (CX)
Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China, Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, Key Laboratory of Biodiversity and Environment on the Qinghai-Tibet Plateau, Ministry of Education, Lhasa, China
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Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans
- Kai Mi,
- Lili Guan,
- Bandhan Sarker,
- Siliang Song,
- Tianjiao Zhou,
- Hongliang Yi,
- Jianzhi Zhang,
- Chuan Xu
- Published: March 19, 2026
- https://doi.org/10.1371/journal.pbio.3003671