A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms

• Lohany Dias Mamede,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Edward Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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• Miwei Hu,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Jaime Vaquer-Alicea,

  Roles Conceptualization, Methodology

  Affiliation Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, Texas, United States of America

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• Amanda R. Titus,

  Roles Formal analysis

  Affiliation Edward Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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• Patricia M. Passos,

  Roles Formal analysis, Methodology

  Affiliation Edward Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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• Erica Lantelme,

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States of America

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• Rachel L. French,

  Roles Investigation

  Affiliation Agilent Technologies, Santa Clara, California, United States of America

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• Paige A. Kirschner,

  Roles Investigation

  Affiliation Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Marc I. Diamond,

  Roles Conceptualization, Funding acquisition

  Affiliation Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, Texas, United States of America

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• Timothy M. Miller,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Yuna M. Ayala

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: yuna.ayala@health.slu.edu

  Affiliation Edward Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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