Engineered romidepsin biosynthetic pathways in Escherichia coli Nissle 1917 improve the efficacy of bacteria-mediated cancer therapy

• Chenghao Ma,

  Roles Investigation, Methodology, Visualization, Writing – original draft

  Affiliation State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China

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• Geng Li,

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China

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• Tao Sun,

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China

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• Ximi Tang,

  Roles Investigation, Methodology

  Affiliation State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China

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• Tong Qiu,

  Roles Investigation, Methodology

  Affiliations State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China, School of Life Sciences, Shandong University, Qingdao, China

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• Jingwen Song,

  Roles Investigation, Methodology

  Affiliations State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China, School of Life Sciences, Shandong University, Qingdao, China

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• Hailong Wang ,

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: wanghailong@sdu.edu.cn (HW); zhangyouming@sdu.edu.cn (YZ); tianyujiang@sdu.edu.cn (TJ)

  Affiliation State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China

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• Youming Zhang ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: wanghailong@sdu.edu.cn (HW); zhangyouming@sdu.edu.cn (YZ); tianyujiang@sdu.edu.cn (TJ)

  Affiliations State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China, Shenzhen Key Laboratory of Genome Manipulation and Biosynthesis, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China

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• Tianyu Jiang

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft

  * E-mail: wanghailong@sdu.edu.cn (HW); zhangyouming@sdu.edu.cn (YZ); tianyujiang@sdu.edu.cn (TJ)

  Affiliation State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University–Helmholtz Institute of Biotechnology, Shandong University, Qingdao, China

  https://orcid.org/0000-0002-9013-5165

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