Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling

• Jie Zhang ,

  Contributed equally to this work with: Jie Zhang, Qian Shan, Xin Wang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: zhangjiea@ynu.edu.cn (JZ); clyang@bch.com.cn (CY)

  Affiliations Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China, MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Qian Shan ,

  Contributed equally to this work with: Jie Zhang, Qian Shan, Xin Wang

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China, MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Xin Wang ,

  Contributed equally to this work with: Jie Zhang, Qian Shan, Xin Wang

  Roles Investigation, Methodology

  Affiliations Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China, MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Meijiao Li,

  Roles Investigation

  Affiliations Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China, MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China, Southwest United Graduate School, Kunming, China

  ⨯
• Yang Yang,

  Roles Investigation

  Affiliations Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China, MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Mei Duan,

  Roles Investigation

  Affiliations Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China, MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Ruofeng Tang,

  Roles Investigation

  Affiliation MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Junxiang Zhou,

  Roles Investigation

  Affiliation MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Fengyang Wang,

  Roles Investigation

  Affiliation MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  ⨯
• Yuehui Shi,

  Roles Methodology

  Affiliation Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China

  ⨯
• Kai Jiang,

  Roles Methodology

  Affiliation Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China

  ⨯
• Chonglin Yang

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhangjiea@ynu.edu.cn (JZ); clyang@bch.com.cn (CY)

  Affiliation MOE Key Laboratory of Major Diseases in Children, National Center for Children’s Health, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

  https://orcid.org/0009-0006-3360-3221

  ⨯