Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans

Yu Wang; Lanxi Wu; Lin Zhang; Yongming Dong; Aaradhya Pant; Yan Liu; Jihong Bai

doi:10.1371/journal.pbio.3003643

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Open Access

Peer-reviewed

Research Article

Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans

Yu Wang ,

Contributed equally to this work with: Yu Wang, Lanxi Wu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Fudan University, Shanghai, P. R. China, Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, P. R. China
⨯
Lanxi Wu ,

Contributed equally to this work with: Yu Wang, Lanxi Wu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Current address: L.W., Scripps Research, La Jolla, California, United States of America

Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Lin Zhang,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Yongming Dong,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – review & editing

Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Aaradhya Pant,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Yan Liu,

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Jihong Bai

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: jbai@fredhutch.org

Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

https://orcid.org/0000-0001-6773-2175

⨯

Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans

Yu Wang,
Lanxi Wu,
Lin Zhang,
Yongming Dong,
Aaradhya Pant,
Yan Liu,
Jihong Bai

Published: February 6, 2026
https://doi.org/10.1371/journal.pbio.3003643

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Synapses
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