The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model

• Zhihui Zhou ,

  Contributed equally to this work with: Zhihui Zhou, Ying Lu, Pan Li

  Roles Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pulmonary and Critical Care Medicine, Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network, and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China

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• Ying Lu ,

  Contributed equally to this work with: Zhihui Zhou, Ying Lu, Pan Li

  Roles Data curation, Formal analysis, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Pan Li ,

  Contributed equally to this work with: Zhihui Zhou, Ying Lu, Pan Li

  Roles Data curation, Investigation, Validation

  Affiliation Department of Pulmonary and Critical Care Medicine, Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network, and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China

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• Xin Liu,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Pulmonary and Critical Care Medicine, Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network, and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China

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• Wei Cheng,

  Roles Funding acquisition, Supervision, Validation, Writing – review & editing

  Affiliation Department of Pulmonary and Critical Care Medicine, Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network, and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China

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• Hai-Ning Chen ,

  Roles Data curation, Formal analysis, Validation

  * E-mail: hnchen@scu.edu.cn (H-NC); lunzhi.dai@scu.edu.cn (LD); hyren@scu.edu.cn (HR)

  Affiliation Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Lunzhi Dai ,

  Roles Formal analysis, Resources, Software, Supervision, Validation, Writing – review & editing

  * E-mail: hnchen@scu.edu.cn (H-NC); lunzhi.dai@scu.edu.cn (LD); hyren@scu.edu.cn (HR)

  Affiliation National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

  https://orcid.org/0000-0002-3003-8910

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• Haiyan Ren

  Roles Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: hnchen@scu.edu.cn (H-NC); lunzhi.dai@scu.edu.cn (LD); hyren@scu.edu.cn (HR)

  Affiliation Department of Pulmonary and Critical Care Medicine, Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network, and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China

  https://orcid.org/0000-0001-9995-3255

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