Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation

• Xiaoxin Guo ,

  Contributed equally to this work with: Xiaoxin Guo, Gang Du, Juanyu Zhou

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing, Conceptualization

  Affiliations West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China

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• Gang Du ,

  Contributed equally to this work with: Xiaoxin Guo, Gang Du, Juanyu Zhou

  Roles Visualization, Writing – original draft, Conceptualization, Methodology

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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• Juanyu Zhou ,

  Contributed equally to this work with: Xiaoxin Guo, Gang Du, Juanyu Zhou

  Roles Investigation, Methodology, Visualization, Writing – review & editing, Conceptualization

  Affiliation West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Fang Fu,

  Roles Methodology

  Affiliation West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yu Yuan,

  Roles Methodology

  Affiliation West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Xingzhu Liu,

  Roles Methodology

  Affiliation West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Haiou Chen,

  Roles Methodology

  Affiliation West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Qianyi Wan,

  Roles Writing – review & editing

  Affiliations West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Bo Gong,

  Roles Visualization

  Affiliation Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China

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• Haiyang Chen

  Roles Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing, Conceptualization

  * E-mail: chenhy82@scu.edu.cn

  Affiliation West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging Research, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

  https://orcid.org/0000-0001-8305-4060

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