Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation

• Ludivine Vasseur,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Céline Gheeraert ,

  Contributed equally to this work with: Céline Gheeraert, Julie Dubois-Chevalier

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Julie Dubois-Chevalier ,

  Contributed equally to this work with: Céline Gheeraert, Julie Dubois-Chevalier

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Ninon Very,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Loïc Guille,

  Roles Investigation, Methodology, Visualization

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Mohamed Bou Saleh,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F-59000, Lille, France

  ⨯
• Clémence Boulet,

  Roles Investigation, Methodology

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Cyril Sobolewski,

  Roles Investigation, Methodology

  Affiliation Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F-59000, Lille, France

  ⨯
• Pascal Loyer,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Inserm, INRAE, Univ Rennes, Institut NUMECAN (Nutrition Métabolismes et Cancer) UMR-A 1341, UMR-S 1317, F-35000, Rennes, France

  ⨯
• Alexandre Berthier,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Noémie Legrand,

  Roles Investigation, Methodology

  Affiliation Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F-59000, Lille, France

  ⨯
• Anne Corlu,

  Roles Methodology, Writing – review & editing

  Affiliation Inserm, INRAE, Univ Rennes, Institut NUMECAN (Nutrition Métabolismes et Cancer) UMR-A 1341, UMR-S 1317, F-35000, Rennes, France

  ⨯
• Viviane Gnemmi,

  Roles Methodology, Resources, Visualization, Writing – review & editing

  Affiliation Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 – CANTHER – Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000, Lille, France

  ⨯
• Guillaume Lasailly,

  Roles Resources

  Affiliation Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F-59000, Lille, France

  ⨯
• Emmanuelle Leteurtre,

  Roles Resources, Writing – review & editing

  Affiliation Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 – CANTHER – Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000, Lille, France

  ⨯
• Dmitry Galinousky,

  Roles Software, Visualization

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Antonino Bongiovanni,

  Roles Methodology, Software

  Affiliation Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 – UAR 2014 – PLBS, Lille, France

  ⨯
• Solenne Taront,

  Roles Investigation

  Affiliation Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F-59000, Lille, France

  ⨯
• Nicolaj I. Toft,

  Roles Methodology, Visualization

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark

  ⨯
• Lars Grøntved,

  Roles Methodology, Visualization

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark

  ⨯
• David Tulasne,

  Roles Resources

  Affiliation Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020 – U1277 – Canther – Cancer Heterogeneity, Plasticity and Resistance to Therapies, Lille, France

  ⨯
• Alessandro Furlan,

  Roles Resources

  Affiliations Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020 – U1277 – Canther – Cancer Heterogeneity, Plasticity and Resistance to Therapies, Lille, France, Tumorigenesis and Resistance to Treatment Unit, Centre Oscar Lambret, F-59000, Lille, France

  ⨯
• Line Carolle Ntandja-Wandji,

  Roles Resources

  Affiliation Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F-59000, Lille, France

  ⨯
• Bart Staels,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Philippe Lefebvre,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  ⨯
• Laurent Dubuquoy,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Univ. Lille, Inserm, CHU Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F-59000, Lille, France

  ⨯
•  [ ... ],
• Jérôme Eeckhoute

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jerome.eeckhoute@inserm.fr

  Affiliation Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000, Lille, France

  https://orcid.org/0000-0002-7222-9264

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