The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in Streptomyces

• Chao Li ,

  Contributed equally to this work with: Chao Li, Mia Urem

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Biology, Leiden University, Leiden, The Netherlands, School of Life Sciences, Anhui Agricultural University, Hefei, Anhui, China

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• Mia Urem ,

  Contributed equally to this work with: Chao Li, Mia Urem

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Institute of Biology, Leiden University, Leiden, The Netherlands, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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• Ioli Kotsogianni,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Biological Chemistry Group, Institute of Biology, Leiden University, Leiden, The Netherlands

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• Josephine Lau,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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• Chao Du,

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Institute of Biology, Leiden University, Leiden, The Netherlands

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• Somayah S. Elsayed,

  Roles Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing

  Affiliation Institute of Biology, Leiden University, Leiden, The Netherlands

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• Nathaniel I. Martin,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Biological Chemistry Group, Institute of Biology, Leiden University, Leiden, The Netherlands

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• Iain W. McNae,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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• Patrick Voskamp,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

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• Christoph Mayer,

  Roles Formal analysis, Resources, Supervision, Writing – review & editing

  Affiliation Institute for Microbiology and Biotechnology, University of Tübingen, Tübingen, Germany

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• Sébastien Rigali,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation InBioS—Center for Protein Engineering, University of Liège, Liège, Belgium

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• Navraj Pannu,

  Roles Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

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• Jan Pieter Abrahams ,

  Roles Conceptualization, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jan-pieter.abrahams@psi.ch (JPA); l.schada.von.borzyskowski@biology.leidenuniv.nl (LSvB); g.wezel@biology.leidenuniv.nl (GPvW)

  Affiliations Biozentrum, Basel University, Basel, Switzerland, Paul Scherrer Institute, Villigen, Switzerland

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• Lennart Schada von Borzyskowski ,

  Roles Conceptualization, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jan-pieter.abrahams@psi.ch (JPA); l.schada.von.borzyskowski@biology.leidenuniv.nl (LSvB); g.wezel@biology.leidenuniv.nl (GPvW)

  Affiliation Institute of Biology, Leiden University, Leiden, The Netherlands

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• Gilles P. van Wezel

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jan-pieter.abrahams@psi.ch (JPA); l.schada.von.borzyskowski@biology.leidenuniv.nl (LSvB); g.wezel@biology.leidenuniv.nl (GPvW)

  Affiliations Institute of Biology, Leiden University, Leiden, The Netherlands, Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Wageningen, The Netherlands

  https://orcid.org/0000-0003-0341-1561

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