The efficacy of longevity interventions in Caenorhabditis elegans is determined by the early life activity of RNA splicing factors

• Sneha Dutta ,

  Contributed equally to this work with: Sneha Dutta, Maria Camila Perez Matos

  Roles Conceptualization, Data curation, Investigation, Writing – original draft

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Maria Camila Perez Matos ,

  Contributed equally to this work with: Sneha Dutta, Maria Camila Perez Matos

  Roles Conceptualization, Data curation, Investigation, Writing – review & editing

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Caroline Heintz,

  Roles Conceptualization, Data curation, Investigation, Writing – review & editing

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Ayse Sena Mutlu,

  Roles Investigation, Methodology

  Affiliations Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America

  ⨯
• Mary Piper,

  Roles Data curation, Formal analysis

  Affiliation Harvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Meeta Mistry,

  Roles Data curation, Methodology, Validation

  Affiliation Harvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Arpit Sharma,

  Roles Investigation

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Christopher S. Morrow,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Hannah Smith,

  Roles Investigation

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Porsha Howell,

  Roles Investigation

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Rohan Sehgal,

  Roles Investigation

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Anne Lanjuin,

  Roles Conceptualization, Data curation, Investigation, Writing – review & editing

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  ⨯
• Meng C. Wang,

  Roles Conceptualization, Supervision

  Affiliations Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America

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• William B. Mair

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: wmair@hsph.harvard.edu

  Affiliation Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-0661-1342

  ⨯