The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

Fengyi Mao; Sai Wu; Derek B. Allison; Daheng He; Yifan Kong; Chaohao Li; Zhiguo Li; Yanquan Zhang; Xinyi Wang; Qiongsi Zhang; Chi Wang; Xiaoqi Liu

doi:10.1371/journal.pbio.3003490

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Open Access

Peer-reviewed

Research Article

The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

Fengyi Mao ,

Contributed equally to this work with: Fengyi Mao, Sai Wu

Roles Conceptualization, Data curation, Methodology, Writing – original draft

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0001-7785-6606

⨯
Sai Wu ,

Contributed equally to this work with: Fengyi Mao, Sai Wu

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Derek B. Allison,

Roles Formal analysis, Writing – review & editing

Affiliations Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Daheng He,

Roles Software, Visualization

Affiliation Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Yifan Kong,

Roles Formal analysis, Methodology

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Chaohao Li,

Roles Data curation, Methodology

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Zhiguo Li,

Roles Methodology

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Yanquan Zhang,

Roles Methodology

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Xinyi Wang,

Roles Methodology, Resources

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Qiongsi Zhang,

Roles Methodology

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Chi Wang,

Roles Resources, Software

Affiliation Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Xiaoqi Liu

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: Xiaoqi.Liu@uky.edu

Affiliations Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0002-6613-1746

⨯

The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

Fengyi Mao,
Sai Wu,
Derek B. Allison,
Daheng He,
Yifan Kong,
Chaohao Li,
Zhiguo Li,
Yanquan Zhang,
Xinyi Wang,
Qiongsi Zhang

Published: November 24, 2025
https://doi.org/10.1371/journal.pbio.3003490

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Melanoma
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