A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day

• Guanhua Sun,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States

  https://orcid.org/0000-0002-3710-2807

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• Tomoyuki Mano,

  Roles Investigation, Methodology, Writing – original draft

  Affiliations Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States, Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Computational Neuroethology Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan

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• Shoi Shi,

  Roles Conceptualization

  Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, International Institute for Integrative Sleep Medicine (IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Alvin Li,

  Roles Visualization

  Affiliation Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States

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• Koji L Ode,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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• Alex Rosi-Andersen,

  Roles Investigation

  Affiliation Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

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• Erica Pedron,

  Roles Investigation

  Affiliation Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

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• Steven A. Brown ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision

  ¶† In memoriam

  Affiliation Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

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• Hiroki R Ueda,

  Roles Funding acquisition

  Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Laboratory of Synthetic Biology, RIKEN Biosystems Dynamics Research, Osaka, Japan, Department of Systems Biology, Institute of Life Science, Kurume University, Fukuoka, Japan

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• Konstantinos Kompotis ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: forger@umich.edu (DBF); konstantinos.kompotis@pharma.uzh.ch (KK)

  Affiliations Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States, Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

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• Daniel B. Forger

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: forger@umich.edu (DBF); konstantinos.kompotis@pharma.uzh.ch (KK)

  Affiliations Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States, Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States

  https://orcid.org/0000-0001-7581-4031

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