Transposable elements contribute substantially to naturally occurring genetic lethality in Drosophila melanogaster

Sarah B. Marion; Katrina Focht; Iman Hamid; Edwin S. Iversen; Hannah John; Brenda Manzano-Winkler; Amber Navarra; Saniya Pangare; Mehrnaz Zarei; Mohamed A. F. Noor

doi:10.1371/journal.pbio.3003467

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Open Access

Peer-reviewed

Research Article

Transposable elements contribute substantially to naturally occurring genetic lethality in Drosophila melanogaster

Sarah B. Marion ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: msarah@reed.edu

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-3910-2421

⨯
Katrina Focht,

Roles Data curation, Investigation, Supervision

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯
Iman Hamid,

Roles Data curation, Formal analysis, Investigation

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯
Edwin S. Iversen,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Statistical Science, Duke University, Durham, North Carolina, United States of America
⨯
Hannah John,

Roles Data curation, Investigation

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯
Brenda Manzano-Winkler,

Roles Data curation, Investigation

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯
Amber Navarra,

Roles Data curation, Investigation

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯
Saniya Pangare,

Roles Investigation, Supervision

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯
Mehrnaz Zarei,

Roles Investigation

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯
Mohamed A. F. Noor

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Biology Department, Duke University, Durham, North Carolina, United States of America
⨯

Transposable elements contribute substantially to naturally occurring genetic lethality in Drosophila melanogaster

Sarah B. Marion,
Katrina Focht,
Iman Hamid,
Edwin S. Iversen,
Hannah John,
Brenda Manzano-Winkler,
Amber Navarra,
Saniya Pangare,
Mehrnaz Zarei,
Mohamed A. F. Noor

Published: March 10, 2026
https://doi.org/10.1371/journal.pbio.3003467

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Drosophila melanogaster
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Insertion mutation
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Invertebrate genomics
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Point mutation
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Deletion mutation
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Evolutionary genetics
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Chromosome mapping
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Mutation
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