Brain-age models with lower age prediction accuracy have higher sensitivity for disease detection

• Marc-Andre Schulz ,

  Contributed equally to this work with: Marc-Andre Schulz, Nys Tjade Siegel

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: marc-andre.schulz@charite.de

  Affiliations Department of Psychiatry and Neurosciences, Charité – Universitätsmedizin Berlin (corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health), Berlin, Germany, Bernstein Center for Computational Neuroscience, Berlin, Germany, Hertie Institute for AI in Brain Health, University of Tübingen, Tübingen, Germany, Tübingen AI Center, University of Tübingen, Tübingen, Germany

  https://orcid.org/0000-0002-1140-1841

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• Nys Tjade Siegel ,

  Contributed equally to this work with: Marc-Andre Schulz, Nys Tjade Siegel

  Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliations Department of Psychiatry and Neurosciences, Charité – Universitätsmedizin Berlin (corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health), Berlin, Germany, Bernstein Center for Computational Neuroscience, Berlin, Germany, Hertie Institute for AI in Brain Health, University of Tübingen, Tübingen, Germany, Tübingen AI Center, University of Tübingen, Tübingen, Germany

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• Kerstin Ritter

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Department of Psychiatry and Neurosciences, Charité – Universitätsmedizin Berlin (corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health), Berlin, Germany, Bernstein Center for Computational Neuroscience, Berlin, Germany, Hertie Institute for AI in Brain Health, University of Tübingen, Tübingen, Germany, Tübingen AI Center, University of Tübingen, Tübingen, Germany

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