Structured water molecules drive activation and G protein selectivity in the GPR174 receptor

• Ying-Jun Dong ,

  Contributed equally to this work with: Ying-Jun Dong, Kun Xi, Ya-Zhi Zhang, Jian-Heng Xue, Dan-Dan Shen

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China

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• Kun Xi ,

  Contributed equally to this work with: Ying-Jun Dong, Kun Xi, Ya-Zhi Zhang, Jian-Heng Xue, Dan-Dan Shen

  Roles Formal analysis, Validation, Writing – original draft

  Affiliation Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China

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• Ya-Zhi Zhang ,

  Contributed equally to this work with: Ying-Jun Dong, Kun Xi, Ya-Zhi Zhang, Jian-Heng Xue, Dan-Dan Shen

  Roles Investigation, Visualization

  Affiliations School of Pharmacy, Hangzhou Medical College, Hangzhou, China, Department of Cardiology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Jian-Heng Xue ,

  Contributed equally to this work with: Ying-Jun Dong, Kun Xi, Ya-Zhi Zhang, Jian-Heng Xue, Dan-Dan Shen

  Roles Investigation

  Affiliation Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China

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• Dan-Dan Shen ,

  Contributed equally to this work with: Ying-Jun Dong, Kun Xi, Ya-Zhi Zhang, Jian-Heng Xue, Dan-Dan Shen

  Roles Investigation

  Affiliations Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China, Center for Structural Pharmacology and Therapeutics Development, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Shao-Kun Zang,

  Roles Investigation

  Affiliation Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China

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• Ruozhu Zhao,

  Roles Writing – review & editing

  Affiliation School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing, China

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• Hai Qi,

  Roles Writing – review & editing

  Affiliation School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing, China

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• Chunyou Mao ,

  Roles Investigation, Supervision, Writing – review & editing

  * E-mail: maochunyou@zju.edu.cn (CM); wweiwei@zju.edu.cn (W-WW); zhang_yan@zju.edu.cn (YZ)

  Affiliations Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China, Center for Structural Pharmacology and Therapeutics Development, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Wei-Wei Wang ,

  Roles Funding acquisition, Writing – review & editing

  * E-mail: maochunyou@zju.edu.cn (CM); wweiwei@zju.edu.cn (W-WW); zhang_yan@zju.edu.cn (YZ)

  Affiliations Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China, Department of Cardiology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

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• Yan Zhang

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: maochunyou@zju.edu.cn (CM); wweiwei@zju.edu.cn (W-WW); zhang_yan@zju.edu.cn (YZ)

  Affiliations Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China, School of Pharmacy, Hangzhou Medical College, Hangzhou, China

  https://orcid.org/0000-0003-2189-0244

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