PRMT5 regulates alternative splicing of TCF3 under hypoxia to promote EMT and invasion in breast cancer

Srinivas Abhishek Mutnuru; Pooja Yadav; Parik Kakani; Shruti Ganesh Dhamdhere; Poorva Kumari; Shruti Agrawal; Atul Samaiya; Sanjeev Shukla

doi:10.1371/journal.pbio.3003444

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Open Access

Peer-reviewed

Research Article

PRMT5 regulates alternative splicing of TCF3 under hypoxia to promote EMT and invasion in breast cancer

Srinivas Abhishek Mutnuru,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh, India
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Pooja Yadav,

Roles Conceptualization, Methodology

Current address: Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh, India
⨯
Parik Kakani,

Roles Investigation, Methodology

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh, India
⨯
Shruti Ganesh Dhamdhere,

Roles Investigation, Methodology

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh, India
⨯
Poorva Kumari,

Roles Investigation, Methodology

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh, India
⨯
Shruti Agrawal,

Roles Resources

Affiliation Department of Pathology, Bansal Hospital, Bhopal, Madhya Pradesh, India
⨯
Atul Samaiya,

Roles Resources

Affiliation Department of Surgical Oncology, Bansal Hospital, Bhopal, Madhya Pradesh, India
⨯
Sanjeev Shukla

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: sanjeevs@iiserb.ac.in

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh, India

https://orcid.org/0000-0003-3361-0588

⨯

PRMT5 regulates alternative splicing of TCF3 under hypoxia to promote EMT and invasion in breast cancer

Srinivas Abhishek Mutnuru,
Pooja Yadav,
Parik Kakani,
Shruti Ganesh Dhamdhere,
Poorva Kumari,
Shruti Agrawal,
Atul Samaiya,
Sanjeev Shukla

Published: October 28, 2025
https://doi.org/10.1371/journal.pbio.3003444

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Hypoxia
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Alternative splicing
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DNA methylation
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Breast cancer
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Histones
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Immunoblotting
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Arginine
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Transfection
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