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Update Articles develop a previous PLOS Biology study by providing new mechanistic insight, identifying the biological or physiological significance of the previous findings, or in another way significantly adding to the original article.
The modern expansion of Dscam1 isoform diversity in Drosophila is linked to fitness and immunity
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Haiyang Dong ,
Contributed equally to this work with: Haiyang Dong, Lili Wu, Zhechao Wang
Roles Data curation, Formal analysis, Funding acquisition, Investigation, Validation, Writing – original draft
* E-mail: dong.hy@zju.edu.cn (HD); jinyf@zju.edu.cn (YJ)
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Lili Wu ,
Contributed equally to this work with: Haiyang Dong, Lili Wu, Zhechao Wang
Roles Data curation, Formal analysis, Investigation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Zhechao Wang ,
Contributed equally to this work with: Haiyang Dong, Lili Wu, Zhechao Wang
Roles Data curation, Formal analysis, Funding acquisition, Investigation
Affiliations MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China, School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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Huiru Qu,
Roles Data curation, Formal analysis, Investigation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Jinpeng Xie,
Roles Data curation, Formal analysis, Investigation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Yaoqi Liu,
Roles Data curation, Formal analysis, Investigation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Jingsong Lv,
Roles Data curation, Investigation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Nengcheng Bao,
Roles Data curation, Formal analysis
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Jian Zhang,
Roles Data curation, Formal analysis
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Pengjuan Guo,
Roles Data curation, Formal analysis
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Ru Yan,
Roles Data curation, Formal analysis, Funding acquisition
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Jiayan Fu,
Roles Data curation, Formal analysis
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Jilong Shi,
Roles Data curation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Ying Fu,
Roles Data curation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Lei Li,
Roles Data curation, Validation
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Yiwen Du,
Roles Data curation, Formal analysis
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Hongru Ma,
Roles Data curation, Formal analysis
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Feng Shi,
Roles Formal analysis
Affiliation MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Jianhua Huang,
Roles Formal analysis
Affiliation Institute of Insect Sciences, Zhejiang University, Hangzhou, Zhejiang, China
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Yongfeng Jin
Roles Formal analysis, Funding acquisition, Project administration, Writing – original draft
* E-mail: dong.hy@zju.edu.cn (HD); jinyf@zju.edu.cn (YJ)
Affiliations MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China, School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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The modern expansion of Dscam1 isoform diversity in Drosophila is linked to fitness and immunity
- Haiyang Dong,
- Lili Wu,
- Zhechao Wang,
- Huiru Qu,
- Jinpeng Xie,
- Yaoqi Liu,
- Jingsong Lv,
- Nengcheng Bao,
- Jian Zhang,
- Pengjuan Guo
- Published: September 12, 2025
- https://doi.org/10.1371/journal.pbio.3003383