The immune receptor SLAMF5 regulates myeloid-cell mediated neuroinflammation in multiple sclerosis

Laura Bellassen; Keren David; Bar Lampert; Avital Sarusi-Portuguez; Michael Tsoory; Jazz Lubliner; Eran Hornstein; Michael Osherov; Ron Milo; Ori Brenner; Shirly Becker-Herman; Idit Shachar

doi:10.1371/journal.pbio.3003373

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Open Access

Peer-reviewed

Research Article

The immune receptor SLAMF5 regulates myeloid-cell mediated neuroinflammation in multiple sclerosis

Laura Bellassen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel
⨯
Keren David,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel
⨯
Bar Lampert,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel
⨯
Avital Sarusi-Portuguez,

Roles Data curation, Formal analysis

Affiliation The Mantoux Bioinformatics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
⨯
Michael Tsoory,

Roles Methodology

Affiliation Behavioral and Physiological Phenotyping Unit, Weizmann Institute of Science, Rehovot, Israel
⨯
Jazz Lubliner,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯
Eran Hornstein,

Roles Methodology, Writing – review & editing

Affiliation Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
⨯
Michael Osherov,

Roles Resources

Affiliation Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel
⨯
Ron Milo,

Roles Resources, Writing – review & editing

Affiliation Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel
⨯
Ori Brenner,

Roles Formal analysis

Affiliation Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel
⨯
Shirly Becker-Herman,

Roles Data curation, Project administration

Affiliation Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel
⨯
Idit Shachar

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – original draft

* E-mail: idit.shachar@weizmann.ac.il

Affiliation Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel

https://orcid.org/0000-0003-0004-6159

⨯

The immune receptor SLAMF5 regulates myeloid-cell mediated neuroinflammation in multiple sclerosis

Laura Bellassen,
Keren David,
Bar Lampert,
Avital Sarusi-Portuguez,
Michael Tsoory,
Jazz Lubliner,
Eran Hornstein,
Michael Osherov,
Ron Milo,
Ori Brenner

Published: September 8, 2025
https://doi.org/10.1371/journal.pbio.3003373

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