The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms

• Mohammad Nafees Ansari ,

  Contributed equally to this work with: Mohammad Nafees Ansari, Somesh K. Jha, Ali Khan

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing, Visualization, Writing – review & editing

  Affiliations Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India, National Institute of Immunology, New Delhi, India

  ⨯
• Somesh K. Jha ,

  Contributed equally to this work with: Mohammad Nafees Ansari, Somesh K. Jha, Ali Khan

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing, Visualization, Writing – review & editing

  Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

  ⨯
• Ali Khan ,

  Contributed equally to this work with: Mohammad Nafees Ansari, Somesh K. Jha, Ali Khan

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India

  ⨯
• Kajal Rajput,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India

  ⨯
• Nishant Pandey,

  Roles Data curation, Investigation, Methodology

  Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

  ⨯
• Dolly Jain,

  Roles Data curation, Investigation, Funding acquisition

  Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

  ⨯
• Rajeshwari Tripathi,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Koita Centre for Digital Health-Ashoka, Trivedi School of Biosciences, Ashoka University, Sonipat, India

  ⨯
• Nihal Medatwal,

  Roles Data curation, Formal analysis, Methodology, Investigation

  Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

  ⨯
• Pankaj Sharma,

  Roles Data curation, Investigation, Funding acquisition

  Affiliation Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India

  ⨯
• Sudeshna Datta,

  Roles Data curation, Investigation, Formal analysis, Funding acquisition, Methodology

  Affiliation National Institute of Immunology, New Delhi, India

  ⨯
• Animesh Kar,

  Roles Data curation, Methodology, Investigation

  Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

  ⨯
• Trishna Pani,

  Roles Data curation, Investigation

  Affiliation Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India

  ⨯
• Sk Asif Ali,

  Roles Data curation, Investigation, Funding acquisition, Methodology

  Affiliation National Institute of Immunology, New Delhi, India

  ⨯
• Kaushavi Cholke,

  Roles Data curation, Investigation, Funding acquisition

  Affiliation Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India

  ⨯
• Kajal Rana,

  Roles Data curation, Investigation

  Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

  ⨯
• Valiya P. Snijesh,

  Roles Data curation, Investigation, Funding acquisition, Methodology

  Affiliations Division of Molecular Medicine, St. Johns Research Institute, St Johns National Academy of Health Sciences, Bangalore, Karnataka, India, Centre for Doctoral Studies, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India

  ⨯
• Geetashree Mukherjee,

  Affiliation Tata Medical Center, Kolkata, West Bengal, India

  ⨯
• Suryanarayana V. S. Deo,

  Roles Resources

  Affiliation Department of Surgical Oncology, BRA-Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

  ⨯
• Soumen Basak,

  Roles Supervision

  Affiliation National Institute of Immunology, New Delhi, India

  ⨯
• Ashutosh Mishra,

  Roles Resources

  Affiliation Department of Surgical Oncology, BRA-Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

  ⨯
• Jyothi S. Prabhu,

  Roles Data curation, Resources

  Affiliation Division of Molecular Medicine, St. Johns Research Institute, St Johns National Academy of Health Sciences, Bangalore, Karnataka, India

  ⨯
• Arnab Mukhopadhyay,

  Roles Resources, Funding acquisition, Supervision

  Affiliation National Institute of Immunology, New Delhi, India

  ⨯
• Avinash Bajaj ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing, Visualization, Writing – review & editing

  * E-mail: bajaj@rcb.res.in (AB); ujjaini.dasgupta@ashoka.edu.in (UD)

  Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

  ⨯
•  [ ... ],
• Ujjaini Dasgupta

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing, Visualization, Writing – review & editing

  * E-mail: bajaj@rcb.res.in (AB); ujjaini.dasgupta@ashoka.edu.in (UD)

  Affiliations Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India, Koita Centre for Digital Health-Ashoka, Trivedi School of Biosciences, Ashoka University, Sonipat, India

  https://orcid.org/0000-0002-2281-078X

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