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Open Access
Peer-reviewed
Research Article
Sublethal executioner caspase activation in hepatocytes promotes liver regeneration through the JAK/STAT3 pathway
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Zhiyuan Cao,
Roles Investigation, Methodology, Validation, Writing – original draft
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Lining Qin,
Roles Investigation, Validation
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Kaixuan Liu,
Roles Data curation, Methodology, Validation
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Chen Yao,
Roles Investigation, Methodology, Visualization
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Enhong Li,
Roles Validation, Visualization
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Xiaoyu Hao,
Roles Validation, Visualization
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Molin Wang,
Roles Data curation
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Baichun Jiang,
Roles Data curation, Methodology
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Yongxin Zou,
Roles Methodology, Resources
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Huili Hu,
Roles Resources
Affiliation Department of Systems Biomedicine and Research Center of Stem Cell and Regenerative Medicine, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
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Qiao Liu,
Roles Data curation, Supervision
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Changshun Shao,
Roles Writing – review & editing
Affiliation State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Suzhou Medical College, Suzhou, Jiangsu, China
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Yaoqin Gong,
Roles Supervision, Writing – review & editing
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Gongping Sun
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: sgp@sdu.edu.cn
Affiliation The Key Laboratory of Experimental Teratology of the Ministry of Education, State Key Laboratory of Reproductive Medicine and Offspring Health, and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
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Sublethal executioner caspase activation in hepatocytes promotes liver regeneration through the JAK/STAT3 pathway
- Zhiyuan Cao,
- Lining Qin,
- Kaixuan Liu,
- Chen Yao,
- Enhong Li,
- Xiaoyu Hao,
- Molin Wang,
- Baichun Jiang,
- Yongxin Zou,
- Huili Hu
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- Published: August 28, 2025
- https://doi.org/10.1371/journal.pbio.3003357