Defining cellular diversity at the swine maternal–fetal interface using spatial transcriptomics and organoids

Cole R. McCutcheon; Allyson Caldwell; Liheng Yang; Elisa Crisci; Jonathan Alex Pasternak; Carolyn B. Coyne

doi:10.1371/journal.pbio.3003302

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Methods and Resources report novel methods, substantial improvements to current methodologies, or informational datasets.

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Defining cellular diversity at the swine maternal–fetal interface using spatial transcriptomics and organoids

Cole R. McCutcheon,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Allyson Caldwell,

Roles Conceptualization, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Liheng Yang,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Elisa Crisci,

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Jonathan Alex Pasternak,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Department of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America
⨯
Carolyn B. Coyne

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: carolyn.coyne@duke.edu

Affiliations Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, United States of America, Duke Human Vaccine Institute, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-1884-6309

⨯

Defining cellular diversity at the swine maternal–fetal interface using spatial transcriptomics and organoids

Cole R. McCutcheon,
Allyson Caldwell,
Liheng Yang,
Elisa Crisci,
Jonathan Alex Pasternak,
Carolyn B. Coyne

Published: August 28, 2025
https://doi.org/10.1371/journal.pbio.3003302

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Trophoblasts
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Gene expression
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Transcriptome analysis
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Swine
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Organoids
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Placenta
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Cell differentiation
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