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Open Access
Peer-reviewed
Research Article
Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load
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Xing-jun Chen,
Roles Data curation, Investigation, Methodology, Validation
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Fei Li,
Roles Data curation, Investigation, Methodology
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Xinyue Zhao,
Roles Data curation, Investigation, Methodology
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Long Chen,
Roles Data curation, Investigation, Methodology
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Jin Xue,
Roles Data curation, Investigation, Methodology
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Zhimo Yao,
Roles Data curation, Formal analysis
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Zuobin Gan,
Roles Data curation, Methodology
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Xiaoyue Lian,
Roles Data curation, Investigation, Methodology
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Zhenghao Liu,
Roles Investigation
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Luyao Tong,
Roles Formal analysis, Investigation
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Qingshan Yan,
Roles Formal analysis, Software
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Linan Qiu,
Roles Formal analysis, Software, Visualization
Affiliations The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Qin Wang,
Roles Data curation, Visualization
Affiliation The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Jiang-fan Chen ,
Contributed equally to this work with: Jiang-fan Chen, Zhihui Li
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: chenjf555@gmail.com (J-fC); smart_dream@wmu.edu.cn (ZL)
Affiliations The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Zhihui Li
Contributed equally to this work with: Jiang-fan Chen, Zhihui Li
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: chenjf555@gmail.com (J-fC); smart_dream@wmu.edu.cn (ZL)
Affiliations The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
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Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load
- Xing-jun Chen,
- Fei Li,
- Xinyue Zhao,
- Long Chen,
- Jin Xue,
- Zhimo Yao,
- Zuobin Gan,
- Xiaoyue Lian,
- Zhenghao Liu,
- Luyao Tong
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- Published: July 24, 2025
- https://doi.org/10.1371/journal.pbio.3003289