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Open Access
Essay
Essays articulate a specific perspective on a topic of broad interest to scientists.
Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response
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Yajing Qiu ,
Contributed equally to this work with: Yajing Qiu, Yihan Xu, Xinyuan Ding
Roles Visualization, Writing – original draft, Writing – review & editing
¶☯ These authors contributed equally to this work.
Affiliations National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China, Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China
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Yihan Xu ,
Contributed equally to this work with: Yajing Qiu, Yihan Xu, Xinyuan Ding
Roles Writing – original draft, Writing – review & editing
¶☯ These authors contributed equally to this work.
Affiliations National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China, Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China
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Xinyuan Ding ,
Contributed equally to this work with: Yajing Qiu, Yihan Xu, Xinyuan Ding
Roles Writing – original draft
¶☯ These authors contributed equally to this work.
Affiliation Department of Pharmacy, Medical Science University and Suzhou Technology China Innovation Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou, China
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Congcong Zhao,
Roles Visualization
Affiliations National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China, Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China
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Hongcheng Cheng ,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: lgd@ism.cams.cn (GL); chenghongcheng1229@foxmail.com (HC)
¶‡ HC and GL also contributed equally to this work.
Affiliations National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China, Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China
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Guideng Li
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: lgd@ism.cams.cn (GL); chenghongcheng1229@foxmail.com (HC)
¶‡ HC and GL also contributed equally to this work.
Affiliations National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China, Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China
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Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response
- Yajing Qiu,
- Yihan Xu,
- Xinyuan Ding,
- Congcong Zhao,
- Hongcheng Cheng,
- Guideng Li
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- Published: July 14, 2025
- https://doi.org/10.1371/journal.pbio.3003284