Structural elucidation of the haptoglobin–hemoglobin clearance mechanism by macrophage scavenger receptor CD163

Ching-Shin Huang; Hui Wang; Joshua B. R. White; Oksana Degtjarik; Cindy Huynh; Kristoffer Brannstrom; Mark T. Horn; Stephen P. Muench; William S. Somers; Javier Chaparro-Riggers; Laura Lin; Lidia Mosyak

doi:10.1371/journal.pbio.3003264

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Open Access

Peer-reviewed

Research Article

Structural elucidation of the haptoglobin–hemoglobin clearance mechanism by macrophage scavenger receptor CD163

Ching-Shin Huang ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Ching-Shin.Huang@pfizer.com (C-SH); Lidia.Moysak@pfizer.com (LM)

Affiliation BioMedicine Design, Pfizer, Inc., Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0002-6435-9309

⨯
Hui Wang,

Roles Conceptualization, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation BioMedicine Design, Pfizer, Inc., La Jolla, California, United States of America
⨯
Joshua B. R. White,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
⨯
Oksana Degtjarik,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
⨯
Cindy Huynh,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation BioMedicine Design, Pfizer, Inc., La Jolla, California, United States of America
⨯
Kristoffer Brannstrom,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation BioMedicine Design, Pfizer, Inc., La Jolla, California, United States of America
⨯
Mark T. Horn,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation BioMedicine Design, Pfizer, Inc., La Jolla, California, United States of America
⨯
Stephen P. Muench,

Roles Methodology, Resources, Supervision, Writing – review & editing

Affiliation School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
⨯
William S. Somers,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation BioMedicine Design, Pfizer, Inc., Cambridge, Massachusetts, United States of America
⨯
Javier Chaparro-Riggers,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation BioMedicine Design, Pfizer, Inc., La Jolla, California, United States of America
⨯
Laura Lin,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation BioMedicine Design, Pfizer, Inc., Cambridge, Massachusetts, United States of America
⨯
Lidia Mosyak

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Ching-Shin.Huang@pfizer.com (C-SH); Lidia.Moysak@pfizer.com (LM)

Affiliation BioMedicine Design, Pfizer, Inc., Cambridge, Massachusetts, United States of America
⨯

Structural elucidation of the haptoglobin–hemoglobin clearance mechanism by macrophage scavenger receptor CD163

Ching-Shin Huang,
Hui Wang,
Joshua B. R. White,
Oksana Degtjarik,
Cindy Huynh,
Kristoffer Brannstrom,
Mark T. Horn,
Stephen P. Muench,
William S. Somers,
Javier Chaparro-Riggers

Published: July 11, 2025
https://doi.org/10.1371/journal.pbio.3003264

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Electron cryo-microscopy
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