Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer’s disease

• Shaokun Chen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Jiechao Zhou,

  Roles Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Shuzhong Wang,

  Roles Data curation, Formal analysis, Software

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Erqu Chen,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Kai Zhuang,

  Roles Investigation, Methodology, Validation

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Raozhou Lin,

  Roles Validation, Visualization, Writing – review & editing

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Chensi Liang,

  Roles Investigation, Methodology, Software

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Dan Can,

  Roles Investigation, Software

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Huifang Li,

  Roles Data curation, Software

  Affiliation Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China

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• Jing Li,

  Roles Methodology, Supervision

  Affiliation Department of Neurointervention, The First Affiliated Hospital of Zhengzhou University, Henan Provincial Neurointerventional Engineering Research Center, Zhengzhou, Henan, China

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• Jie Zhang

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jiezhang@xmu.edu.cn

  Affiliations Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian, China, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, Hebei, China, Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China

  https://orcid.org/0000-0003-1040-5848

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