Structure of human glycoprotein 2 reveals mechanisms underlying filament formation and adaption to proteolytic environment in the digestive tract

Jianting Han; Meinai Song; Yijia Cheng; Wei Gong; Fei Zhang; Qin Cao

doi:10.1371/journal.pbio.3003238

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Structure of human glycoprotein 2 reveals mechanisms underlying filament formation and adaption to proteolytic environment in the digestive tract

Jianting Han,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China

https://orcid.org/0009-0007-4067-1908

⨯
Meinai Song,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
⨯
Yijia Cheng,

Roles Investigation, Writing – review & editing

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
⨯
Wei Gong,

Roles Resources, Writing – review & editing

Affiliation Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Research Center of Biliary Tract Disease, Shanghai, China
⨯
Fei Zhang ,

Roles Resources, Writing – review & editing

* E-mail: caoqin@sjtu.edu.cn (QC); zhangfei@xinhuamed.com.cn (FZ)

Affiliation Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Research Center of Biliary Tract Disease, Shanghai, China
⨯
Qin Cao

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: caoqin@sjtu.edu.cn (QC); zhangfei@xinhuamed.com.cn (FZ)

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China

https://orcid.org/0000-0003-4207-2697

⨯

Structure of human glycoprotein 2 reveals mechanisms underlying filament formation and adaption to proteolytic environment in the digestive tract

Jianting Han,
Meinai Song,
Yijia Cheng,
Wei Gong,
Fei Zhang,
Qin Cao

Published: June 23, 2025
https://doi.org/10.1371/journal.pbio.3003238

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Electron cryo-microscopy
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Pancreas
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Gastrointestinal tract
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Glycosylation
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