Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model

Sumedha Ravishankar; Samantha M. Tuohey; Nicole O. Ramos; Satoshi Uchiyama; Megan I. Hayes; Kalisa Kang; Victor Nizet; Cressida A. Madigan

doi:10.1371/journal.pbio.3003236

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Open Access

Peer-reviewed

Research Article

Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model

Sumedha Ravishankar,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Biological Sciences, UC San Diego, La Jolla, California, United States of America, Biological Sciences Graduate Program, UC San Diego, La Jolla, California, United States of America
⨯
Samantha M. Tuohey,

Roles Data curation, Formal analysis, Investigation

Affiliation School of Biological Sciences, UC San Diego, La Jolla, California, United States of America
⨯
Nicole O. Ramos,

Roles Data curation, Investigation

Affiliation School of Biological Sciences, UC San Diego, La Jolla, California, United States of America
⨯
Satoshi Uchiyama,

Roles Investigation, Methodology

Affiliation Department of Pediatrics, School of Medicine, UC San Diego, La Jolla, California, United States of America
⨯
Megan I. Hayes,

Roles Resources, Writing – review & editing

Affiliations School of Biological Sciences, UC San Diego, La Jolla, California, United States of America, Biological Sciences Graduate Program, UC San Diego, La Jolla, California, United States of America
⨯
Kalisa Kang,

Roles Investigation, Methodology

Affiliation School of Biological Sciences, UC San Diego, La Jolla, California, United States of America
⨯
Victor Nizet,

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliations Department of Pediatrics, School of Medicine, UC San Diego, La Jolla, California, United States of America, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, United States of America
⨯
Cressida A. Madigan

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: cmadigan@ucsd.edu

Affiliation School of Biological Sciences, UC San Diego, La Jolla, California, United States of America

https://orcid.org/0000-0003-3270-7142

⨯

Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model

Sumedha Ravishankar,
Samantha M. Tuohey,
Nicole O. Ramos,
Satoshi Uchiyama,
Megan I. Hayes,
Kalisa Kang,
Victor Nizet,
Cressida A. Madigan

Published: July 3, 2025
https://doi.org/10.1371/journal.pbio.3003236

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Larvae
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Endothelial cells
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Fluorescence imaging
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Zebrafish
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Blood vessels
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Cell death
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Meningitis
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Cell staining
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