Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors

• Indi P. Joore,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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• Sawsan Shehata,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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• Irena Muffels,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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• Jose Castro-Alpízar,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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• Elena Jiménez-Curiel,

  Roles Investigation, Methodology

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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• Emilia Nagyova,

  Roles Investigation, Methodology

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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• Natacha Levy,

  Roles Formal analysis

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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• Ziqin Tang,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliations Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, Oncode Institute, Utrecht, The Netherlands

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• Kimberly Smit,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliations Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, Oncode Institute, Utrecht, The Netherlands

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• Wilbert P. Vermeij,

  Roles Formal analysis, Funding acquisition, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliations Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, Oncode Institute, Utrecht, The Netherlands

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• Richard Rodenburg,

  Roles Investigation, Resources

  Affiliations Department of Pediatrics, Radboud UMC, Nijmegen, The Netherlands, Department of Genetics, Radboud UMC, Nijmegen, The Netherlands

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• Raymond Schiffelers,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation CDL Research, UMC Utrecht, Utrecht, The Netherlands

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• Edward E.S. Nieuwenhuis,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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• Peter M. van Hasselt,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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• Sabine A. Fuchs ,

  Contributed equally to this work with: Sabine A. Fuchs, Martijn A. J. Koppens

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: s.fuchs@umcutrecht.nl (SAF); m.a.j.koppens@umcutrecht.nl (MAJK)

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

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•  [ ... ],
• Martijn A. J. Koppens

  Contributed equally to this work with: Sabine A. Fuchs, Martijn A. J. Koppens

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: s.fuchs@umcutrecht.nl (SAF); m.a.j.koppens@umcutrecht.nl (MAJK)

  Affiliations Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands, Regenerative Medicine Center Utrecht, Utrecht, The Netherlands

  https://orcid.org/0000-0003-2912-2266

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