Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures

• Aubrey Converse ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: aubrey.converse@northwestern.edu (AC); mpritchard@kumc.edu (MTP)

  Affiliation Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

  https://orcid.org/0000-0002-4203-1687

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• Madeline J. Perry,

  Roles Investigation, Visualization

  Affiliation Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Shweta S. Dipali,

  Roles Formal analysis

  Affiliation Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Jose V. V. Isola,

  Roles Formal analysis, Writing – review & editing

  Affiliation Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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• Emmett B. Kelly,

  Roles Formal analysis

  Affiliation Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Joseph M. Varberg,

  Roles Writing – review & editing

  Affiliation Stowers Institute for Medical Research, Kansas City, Missouri, United States of America

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• Mary B. Zelinski,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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• Michael B. Stout,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Oklahoma City Veterans Affairs Medical Center, Oklahoma City, Oklahoma, United States of America

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• Michele T. Pritchard ,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  * E-mail: aubrey.converse@northwestern.edu (AC); mpritchard@kumc.edu (MTP)

  Affiliations Department of Pharmacology, Toxicology & Therapeutics University of Kansas Medical Center, Kansas City, Kansas, United States of America, Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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• Francesca E. Duncan

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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