Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism

Ruiying Ma; Muwon Kang; Gyu Hyun Kim; Hyojin Kang; Sunho Lee; Yeji Yang; Hea Ji Lee; Seungji Choi; Seungsoo Kim; Seoyeong Kim; Yukyung Jun; Hyewon Kim; Yinhua Zhang; U Suk Kim; Hyae Rim Kang; Yoonhee Kim; Yulim Lee; Woosuk Chung; Eun Jung Lee; Serk In Park; Eunha Kim; Minji Jeon; Geum-Sook Hwang; Jungmin Choi; Youngae Jung; Jin Young Kim; Eunjoon Kim; Kea Joo Lee; Kihoon Han

doi:10.1371/journal.pbio.3003192

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Methods and Resources report novel methods, substantial improvements to current methodologies, or informational datasets.

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Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism

Ruiying Ma ,

Contributed equally to this work with: Ruiying Ma, Muwon Kang, Gyu Hyun Kim

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea, BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Muwon Kang ,

Contributed equally to this work with: Ruiying Ma, Muwon Kang, Gyu Hyun Kim

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, Republic of Korea
⨯
Gyu Hyun Kim ,

Contributed equally to this work with: Ruiying Ma, Muwon Kang, Gyu Hyun Kim

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliations Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea, Neural Circuits Research Group, Korea Brain Research Institute, Daegu, Republic of Korea
⨯
Hyojin Kang,

Roles Data curation, Formal analysis, Funding acquisition, Visualization

Affiliation Division of National Supercomputing, Korea Institute of Science and Technology Information, Daejeon, Republic of Korea
⨯
Sunho Lee,

Roles Formal analysis, Investigation, Methodology

Affiliations Integrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea, Graduate School of Pharmaceutical Sciences, Ewha Womans University College of Pharmacy, Seoul, Republic of Korea
⨯
Yeji Yang,

Roles Formal analysis, Investigation, Methodology

Affiliations Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, Digital Omics Research Center, Korea Basic Science Institute, Ochang, Republic of Korea
⨯
Hea Ji Lee,

Roles Data curation, Formal analysis, Investigation

Affiliation Digital Omics Research Center, Korea Basic Science Institute, Ochang, Republic of Korea
⨯
Seungji Choi,

Roles Data curation, Formal analysis, Methodology, Software, Visualization

Affiliations BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Seungsoo Kim,

Roles Data curation, Formal analysis, Methodology, Software

Affiliations BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Seoyeong Kim,

Roles Data curation, Formal analysis, Investigation

Affiliations Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, Republic of Korea
⨯
Yukyung Jun,

Roles Data curation, Funding acquisition, Methodology, Software

Affiliation Division of National Supercomputing, Korea Institute of Science and Technology Information, Daejeon, Republic of Korea
⨯
Hyewon Kim,

Roles Data curation, Formal analysis, Software

Affiliation Division of National Supercomputing, Korea Institute of Science and Technology Information, Daejeon, Republic of Korea
⨯
Yinhua Zhang,

Roles Formal analysis, Investigation, Visualization

Affiliation Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea
⨯
U Suk Kim,

Roles Formal analysis, Investigation

Affiliations Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea, BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Hyae Rim Kang,

Roles Formal analysis, Funding acquisition, Investigation

Affiliation Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Yoonhee Kim,

Roles Formal analysis, Investigation

Affiliation Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Yulim Lee,

Roles Formal analysis, Investigation

Affiliations Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea
⨯
Woosuk Chung,

Roles Formal analysis, Investigation

Affiliations Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea
⨯
Eun Jung Lee,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliations BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Serk In Park,

Roles Data curation, Formal analysis, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Republic of Korea, Vanderbilt Center for Bone Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Eunha Kim,

Roles Formal analysis, Investigation

Affiliations Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea, BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Minji Jeon,

Roles Data curation, Investigation

Affiliations BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Geum-Sook Hwang,

Roles Data curation, Investigation

Affiliations Integrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea, Chung-Ang University College of Pharmacy, Seoul, Republic of Korea
⨯
Jungmin Choi,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software

Affiliations BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea, Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Youngae Jung ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – review & editing

* E-mail: jya0819@kbsi.re.kr (YJ); jinyoung@kbsi.re.kr (JYK); kime@kaist.ac.kr (EK); relaylee@kbri.re.kr (KJL); neurohan@korea.ac.kr (KH)

Affiliation Integrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea
⨯
Jin Young Kim ,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – review & editing

* E-mail: jya0819@kbsi.re.kr (YJ); jinyoung@kbsi.re.kr (JYK); kime@kaist.ac.kr (EK); relaylee@kbri.re.kr (KJL); neurohan@korea.ac.kr (KH)

Affiliations Digital Omics Research Center, Korea Basic Science Institute, Ochang, Republic of Korea, Chung-Ang University College of Pharmacy, Seoul, Republic of Korea
⨯
Eunjoon Kim ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: jya0819@kbsi.re.kr (YJ); jinyoung@kbsi.re.kr (JYK); kime@kaist.ac.kr (EK); relaylee@kbri.re.kr (KJL); neurohan@korea.ac.kr (KH)

Affiliations Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, Republic of Korea
⨯
Kea Joo Lee ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

* E-mail: jya0819@kbsi.re.kr (YJ); jinyoung@kbsi.re.kr (JYK); kime@kaist.ac.kr (EK); relaylee@kbri.re.kr (KJL); neurohan@korea.ac.kr (KH)

Affiliation Neural Circuits Research Group, Korea Brain Research Institute, Daegu, Republic of Korea
⨯
[ ... ],
Kihoon Han

Roles Conceptualization, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jya0819@kbsi.re.kr (YJ); jinyoung@kbsi.re.kr (JYK); kime@kaist.ac.kr (EK); relaylee@kbri.re.kr (KJL); neurohan@korea.ac.kr (KH)

Affiliations Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea, BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea

https://orcid.org/0000-0002-5925-2152

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Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism

Ruiying Ma,
Muwon Kang,
Gyu Hyun Kim,
Hyojin Kang,
Sunho Lee,
Yeji Yang,
Hea Ji Lee,
Seungji Choi,
Seungsoo Kim,
Seoyeong Kim

Published: October 9, 2025
https://doi.org/10.1371/journal.pbio.3003192

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