Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice

• Hiroyuki J. Kanaya ,

  Contributed equally to this work with: Hiroyuki J. Kanaya, Ken Kuwajima

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  ⨯
• Ken Kuwajima ,

  Contributed equally to this work with: Hiroyuki J. Kanaya, Ken Kuwajima

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation

  Current address: Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan

  Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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• Yuko Ito,

  Roles Investigation, Methodology, Resources

  Affiliation Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan

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• Yuta Shinohara,

  Roles Funding acquisition, Investigation, Methodology, Resources

  Current address: Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

  Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

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• Yohei Okubo,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, Japan

  ⨯
• Shinnosuke Shiono,

  Roles Methodology

  Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  ⨯
• Fumiya Tatsuki,

  Roles Methodology

  Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  ⨯
• Rei-ichiro Ohno,

  Roles Methodology, Resources

  Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  ⨯
• Hideki Ukai,

  Roles Methodology, Resources

  Current address: International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

  ⨯
• Maki Ukai-Tadenuma,

  Roles Methodology, Resources

  Current address: International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

  ⨯
• Kenta Sumiyama,

  Roles Methodology, Resources

  Current address: Laboratory of Animal Genetics and Breeding, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Japan

  Affiliation Laboratory for Mouse Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

  ⨯
• Hiroshi Fujishima,

  Roles Methodology, Resources

  Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan, Department of Systems Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan

  ⨯
• Rikuhiro G. Yamada,

  Roles Methodology, Resources

  Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan, Department of Systems Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan

  ⨯
• Daisuke Tone,

  Roles Methodology, Resources

  Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

  ⨯
• Hiroshi Kiyonari,

  Roles Funding acquisition, Methodology, Resources

  Affiliation Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Japan

  ⨯
• Masaki Kikuchi,

  Roles Investigation, Methodology

  Current address: Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

  Affiliation Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Tsurumi, Yokohama, Japan

  ⨯
• Takashi Umehara,

  Roles Investigation, Methodology

  Current address: College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan

  Affiliation Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Tsurumi, Yokohama, Japan

  ⨯
• Takashi Murayama,

  Roles Funding acquisition, Methodology, Resources

  Affiliation Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, Japan

  ⨯
• Kazunori Kanemaru,

  Roles Methodology, Resources

  Affiliation Department of Physiology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

  ⨯
• Masamitsu Iino,

  Roles Methodology, Resources

  Affiliation Department of Physiology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

  ⨯
• Koji L. Ode,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

  ⨯
• Takatsugu Hirokawa,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

  Affiliations Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, Division of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan

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•  [ ... ],
• Hiroki R. Ueda

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: uedah-tky@umin.ac.jp

  Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan, Department of Systems Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan

  https://orcid.org/0000-0001-8342-9176

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