Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period

Pierre-Yves Barelle; Fabienne Schaller; Soyoung Park; Emilie Caron; Jessica Klucznik; Phillipe Ciofi; Françoise Muscatelli; Sebastien G. Bouret

doi:10.1371/journal.pbio.3003158

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Peer-reviewed

Research Article

Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period

Pierre-Yves Barelle,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations University of Lille, Inserm, CHU Lille, Laboratory Lille Neuroendocrinology, Lille Neuroscience and Cognition, Lille, France, FHU 1000 Days for Health, School of Medicine, Lille, France
⨯
Fabienne Schaller,

Roles Data curation, Methodology

Affiliation Institut de Neurobiologie de la Méditerranée (INMED), INSERM, Aix Marseille Université, Marseille, France
⨯
Soyoung Park,

Roles Data curation, Methodology

Affiliation Children’s Hospital Los Angeles, Los Angeles, California, United States of America
⨯
Emilie Caron,

Roles Data curation, Methodology

Affiliations University of Lille, Inserm, CHU Lille, Laboratory Lille Neuroendocrinology, Lille Neuroscience and Cognition, Lille, France, FHU 1000 Days for Health, School of Medicine, Lille, France
⨯
Jessica Klucznik,

Roles Data curation, Methodology

Affiliations University of Lille, Inserm, CHU Lille, Laboratory Lille Neuroendocrinology, Lille Neuroscience and Cognition, Lille, France, FHU 1000 Days for Health, School of Medicine, Lille, France
⨯
Phillipe Ciofi,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Université de Bordeaux, Inserm, Neurocentre Magendie, Bordeaux, France
⨯
Françoise Muscatelli,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation Institut de Neurobiologie de la Méditerranée (INMED), INSERM, Aix Marseille Université, Marseille, France
⨯
Sebastien G. Bouret

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

* E-mail: sebastien.bouret@inserm.fr

Affiliations University of Lille, Inserm, CHU Lille, Laboratory Lille Neuroendocrinology, Lille Neuroscience and Cognition, Lille, France, FHU 1000 Days for Health, School of Medicine, Lille, France

https://orcid.org/0000-0002-4174-9769

⨯

Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period

Pierre-Yves Barelle,
Fabienne Schaller,
Soyoung Park,
Emilie Caron,
Jessica Klucznik,
Phillipe Ciofi,
Françoise Muscatelli,
Sebastien G. Bouret

Published: November 12, 2025
https://doi.org/10.1371/journal.pbio.3003158

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Exocytosis
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