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Open Access
Peer-reviewed
Research Article
Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans
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Juliana Zimmermann ,
Contributed equally to this work with: Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Christian Sorg, Benedikt Zott
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing
Affiliations Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany, Department of Anesthesiology and Intensive Care, School of Medicine and Health, Technical University of Munich, Munich, Germany, TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Clara Boudriot ,
Contributed equally to this work with: Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Christian Sorg, Benedikt Zott
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Christiane Eipert ,
Contributed equally to this work with: Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Christian Sorg, Benedikt Zott
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Gabriel Hoffmann,
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Rachel Nuttall,
Roles Data curation, Formal analysis, Methodology
Affiliations Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany, Department of Anesthesiology and Intensive Care, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Viktor Neumaier,
Roles Formal analysis, Methodology, Software, Visualization, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Moritz Bonhoeffer,
Roles Formal analysis, Methodology, Software, Visualization, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Sebastian Schneider,
Roles Data curation, Investigation
Affiliations Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany, TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Lena Schmitzer,
Roles Data curation, Investigation
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Jan Kufer,
Roles Data curation, Investigation
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Stephan Kaczmarz,
Roles Investigation, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Dennis M Hedderich,
Roles Investigation, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Andreas Ranft,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Department of Anesthesiology and Intensive Care, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Daniel Golkowski,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliations Department of Neurology, School of Medicine, Technical University of Munich, Munich, Germany, Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
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Josef Priller,
Roles Investigation, Resources, Writing – review & editing
Affiliations Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Munich, Germany, Charité - Universitätsmedizin Berlin and DZNE, Neuropsychiatry, Berlin, Germany, University of Edinburgh and UKI DRI, Edinburgh, United Kingdom
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Claus Zimmer,
Roles Funding acquisition, Methodology, Resources, Writing – review & editing
Affiliation Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Rüdiger Ilg,
Roles Data curation, Writing – review & editing
Affiliations Department of Neurology, School of Medicine, Technical University of Munich, Munich, Germany, Department of Neurology, Asklepios Stadtklinik Bad Tölz, Bad Tölz, Germany
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Gerhard Schneider,
Roles Investigation, Writing – review & editing
Affiliation Department of Anesthesiology and Intensive Care, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Christine Preibisch,
Roles Data curation, Formal analysis, Methodology, Software, Supervision, Writing – review & editing
Affiliations Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany, TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany, Department of Neurology, School of Medicine, Technical University of Munich, Munich, Germany
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Christian Sorg ,
Contributed equally to this work with: Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Christian Sorg, Benedikt Zott
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: Christian.sorg@tum.de (CS); benedikt.zott@tum.de (BZ)
Affiliations Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany, TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany, Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Munich, Germany
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Benedikt Zott
Contributed equally to this work with: Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Christian Sorg, Benedikt Zott
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Christian.sorg@tum.de (CS); benedikt.zott@tum.de (BZ)
Affiliations Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Munich, Germany, TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany, Institute for Neuroscience, Technical University of Munich, Germany, TUM Institute for Advanced Study, Garching, Germany
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Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans
- Juliana Zimmermann,
- Clara Boudriot,
- Christiane Eipert,
- Gabriel Hoffmann,
- Rachel Nuttall,
- Viktor Neumaier,
- Moritz Bonhoeffer,
- Sebastian Schneider,
- Lena Schmitzer,
- Jan Kufer
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- Published: April 24, 2025
- https://doi.org/10.1371/journal.pbio.3003138