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Open Access
Peer-reviewed
Research Article
A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia
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Magnus Ölander,
Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Daniel Rea Vázquez,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Karsten Meier,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Aakriti Singh,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Amanda Silva de Sousa,
Roles Formal analysis, Investigation
Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America
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Fabiola Puértolas-Balint,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Milica Milivojevic,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Lieke Mooij,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Johanna Fredlund,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Eduard Calpe Bosch,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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María Rayón Díaz,
Roles Formal analysis, Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Moa Lundgren,
Roles Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Karin van der Wal,
Roles Investigation
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Shaochun Zhu,
Roles Investigation
Affiliations The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden, Department of Chemistry, Umeå University, Umeå, Sweden
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André Mateus,
Roles Formal analysis, Funding acquisition, Investigation, Supervision, Writing – review & editing
Affiliations The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden, Department of Chemistry, Umeå University, Umeå, Sweden
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Bjoern O. Schroeder,
Roles Funding acquisition, Supervision, Writing – review & editing
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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Jeremy R. Lohman,
Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing
Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America
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Barbara S. Sixt
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: barbara.sixt@umu.se
Affiliations Department of Molecular Biology, Umeå University, Umeå, Sweden, The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden
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A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia
- Magnus Ölander,
- Daniel Rea Vázquez,
- Karsten Meier,
- Aakriti Singh,
- Amanda Silva de Sousa,
- Fabiola Puértolas-Balint,
- Milica Milivojevic,
- Lieke Mooij,
- Johanna Fredlund,
- Eduard Calpe Bosch
- Published: April 29, 2025
- https://doi.org/10.1371/journal.pbio.3003123